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Publications
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2000-present Liu, Y.; Kim, B.; Taylor, S. D. “Synthesis of 4-Formyl Estrone using a Positional Protecting Group and its Conversion to other C-4-Substituted Estrogens.” J. Org. Chem. 2007, in press. Navidpour, L. Lu., W.; Taylor, S.D. “Synthesis of alpha-Fluorosulfonate and alpha-Fluorosulfonamide Analogues of a Sulfated Carbohydrate.” Org. Lett., 2006, 8, 5617-5620. Taylor, S.D.; Mirzaei, F.; Sharifi A.; Bearne, S.L. “Synthesis of Methylene- and Difluoromethylenephosphonate Analogs of Uridine-4-Phosphate and 3-Deazauridine-4-Phosphate.” J. Org. Chem. 2006, 71, 9420-9430. Ahmed, V.; Liu, Y.; Silvestro, C.; Taylor, S.D. “Boronic Acids as Inhibitors of Steroid Sulfatase.” Biooorg. Med. Chem., 2006, 14, 8564-8573. Hill, B; Ahmed, V.; Bates, D.; Taylor, S.D. “Enantioselective Synthesis of Protected L-4-[Sulfonamido(difluoromethyl)]phenylalanine and L-4-[Sulfonamido(methyl)]phenylalanine and an Examination of Hexa- and tripeptide platforms for evaluating pTyr Mimics for PTP1B Inhibition.” J. Org. Chem. 2006; 71, 8190-8197. Taylor, S.D.; Mirzaei, F.; Bearne, S.L. “An Unsymmetrical Approach to the Synthesis of Bis-Methylene Triphosphate Analogues.” Org. Lett. 2006, 8, 4243-4246. Ingram, L.; Taylor, S. D. “Introduction of 2,2,2-Trichloroethyl-Protected Sulfates into Monosaccharides using a Sulfuryl Imidazolium Salt and it’s application to the Synthesis of Sulfated Carbohydrates.” Angew. Chem. Int. Ed. Engl., 2006, 3503-3506. Cecchi, A.; Taylor, S.D.; Liu, Y.; Hill, B.; Vullo, D.; Scozzafava, A.; Supuran, C.T. “Carbonic anhydrase inhibitors: Inhibition of the human enzyms I, II, VA and IX with a library of substituted difluoromethanesulfonamides.” Bioorg. Med. Chem. Lett. 2005, 15, 5192-5196 Liu, Y.; Ahmed, V.; Hill, B.; Taylor, S.D. “Synthesis of a non-hydrolyzable estrone sulfate analogue bearing the difluoromethanesulfonamide group and its evaluation as a steriod sulfatase inhibitor.” Org. Biomol. Chem. 2005, 3, 3329-3335. Ahmed, V.; Ispahany, M.; Ruttgaizer, S.; Guillemette, G.; Taylor, S.D. "A fluorogenic substrate for the continuous assaying of aryl sulfatases." Anal. Biochem. 2005, 340, 80-88. Lu, Wallach; Navidpour, L.; Taylor, S.D. "An Expedient Synthesis of Benzyl 2,3,4-tri-O-benzyl-b-D-glucopyranoside and Benzyl-2,3,4-tri-O-benzyl-b-D-mannopyranoside." Carbohydrate Res. 2005, 340, 1213-1217. Hill, B.; Liu, Y.; Taylor, S. D. "Synthesis of a-Fluorosulfonamides by Electrophilic Fluorination." Org. Lett. 2004, 6, 4285-4288. Taylor, S. D.; Hill, B. "Recent Advances in PTP1B Inhibitors." Expert Opinion on Investigational Drugs, 2004, 13, 199-214 (invited review article). Liu, Y.; Lien, I-F. F.; Ruttgaizer, S.; Dove, P.; Taylor, S. D. " Synthesis and Protection of Aryl Sulfates Using the 2,2,2-Trichloroethyl Moiety." Org. Lett. 2004, 6, 209-212. Lapierre, J.; Ahmed, V.; Chen, M-J.; Ispahany, I.; Guillemette, J. G.; Taylor, S. D. The Difluoromethylene Group as a Replacement for the Labile Oxygen in Steroid Sulfates: A New Approach to Steroid Sulfatase Inhibitors." Bioorg. Med. Chem. Lett. 2004, 14, 151-155. St. Maurice, M.; Bearne, S. L.; Lu, W.; Taylor, S.D. Inhibition of Mandelate Racemase by a-Fluorophophonates. Bioorg. Med. Chem. Lett. 2003, 13, 2041-2044. Taylor, S. D. "Inhibitors of Protein Tyrosine Phosphatase 1B." Current Topics in Medicinal Chemistry, 2003, 3, 759-782 (invited review article). Hum, G.; Lee, J.; Taylor, S. D. "Synthesis of [Difluoro-(3-alkenylphenyl)-methyl]-phosphonic acids on non-crosslinked polystyrene and their evaluation as inhibitors of PTP1B." Bioorg Med Chem. 2002, 12, 3471-3475. Leung, C.; Lee, J.; Meyer, N., Jia, C.; Grzyb, J.; Liu, S.; Hum G.; Taylor, S. D. "The difluoromethylenesulfonic acid group as a monoanionic phosphate surrogate for obtaining PTP1B inhibitors.” Bioorg. Med. Chem. 2002, 10, 2309-2323. Jia, Z.; Ye, Q.; Dinaut, A.N.; Wang, Q.; Waddleton, D.; Payette, P.; Ramachandran, C.; Kennedy, B.; Hum, G. Taylor, S.D. “Structure of Protein Tyrosine Phosphatase 1B in Complex with Inhibitors Bearing Two Phosphotyrosine Mimetics.” J. Med. Chem. 2001, 44, 4584-4594. Dinaut, A.N.; Taylor, S.D. “Antibody-Catalyzed Activation of a Model Tripartate Prodrug by a Tandem hydrolysis-1,6-Elimination Reaction.” J. Chem. Soc. Chem. Commun. 2001, 1386-1387. Liu, S.; Dockendorf, C.; Taylor, S.D. “Synthesis of Protected L-4-[Sulfono(difluoromethyl)]phenylalanine and its Incorporation into a Peptide.” Org. Lett. 2001, 3, 1571-1574. Hum, G.; Wooler, K.; Lee, J.; Taylor, S.D. “Cyclic Five-Membered Phosphinate Esters as Transition State Analogues for Obtaining Phosphohydrolase Antibodies.” Can. J. Chem., 2000, 78, 642-655. Hum, G.; Grzyb, J.; Taylor, S.D. “Synthesis of Non-Peptidyl a,a-Difluoromethylenephosphonic Acids on a Soluble Polymer Support.” J. Combi. Chem., 2000, 2, 234-242. Dinaut, A. N.; Chen, M-J.; Lea, M. Marks, A.; Taylor, S. D. “Antibody-Catalyzed Hydrolysis of an N-Methyl Carbamate.” J. Chem. Soc. Chem. Commun, 2000, 385 Kotoris, C.; Wen, W.; Taylor, S. D. “Preparation of Chiral a-Monofluorophosphonic Acids and Their Evaluation as Inhibitors of Protein Tyrosine Phosphatases.” J. Chem. Soc. Perkin Trans. I, 2000, 1271.
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