Femtomedicine (FMD) and Cancer Therapies:

  1. CR Wang, J Mahmood, QR Zhang, A Vedadi, J Warrington, N Ou, RG Bristow, DA Jaffray, QB Lu, In Vitro and In Vivo Studies of a New Class of Anticancer Molecules for Targeted Radiotherapy of Cancer. Mol. Cancer Ther. 15, 640-650 (2016). This article is featured in Highlights of This Issue (http://mct.aacrjournals.org/content/15/4/531.full).

  1. QB Lu, QR Zhang, N Ou, CR Wang and J Warrington. In vitro and in vivo Studies of Non-Platinum-Based Halogenated Compounds as a New Class of Potent Anti-tumor Agents for Natural Targeted Chemotherapy of Cancers. EBioMedicine 2: 544-553 (2015). Selected by Elsevier for a Press Release:https://www.elsevier.com/about/press-releases/research-and-journals/scientists-discover-new-molecules-that-kill-cancer-cells-and-protect-healthy-cells, and highlighted by a commentary article in EBioMD.

  1. LY Lu, N. Ou, & QB Lu, Antioxidant Induces DNA Damage, Cell Death and Mutagenicity in Human Lung and Skin Normal Cells. Sci. Rep. 3, 3169(1-11) (2013). This paper provides the first demonstration of a reductive DNA damaging mechanism in the cellular process and a plausible mechanism for the harmful effects of antioxidants.

  1. T Luo, J Yu, J Nguyen, CR Wang, RG Bristow, DA Jaffray, XZ Zhou, KP Lu, QB Lu, Electron-Transfer Based Combination Therapy of Cisplatin with Tetramethyl-p-Phenylenediamine for Ovarian, Cervical and Lung Cancers, Proc. Natl. Acad. Sci. USA (PNAS) 109, 10175-10180(2012).

  1. J Nguyen, Y Ma, T Luo, RG Bristow, DA Jaffray, QB Lu, Direct Observation of Ultrafast Electron Transfer Reactions Unravels High Effectiveness of Reductive DNA Damage. Proc. Natl. Acad. Sci. USA (PNAS) 108, 11778-11783 (2011). Highlighted "In This Issue" of the July 19 2011 print issue of PNAS ("Reductive DNA damage from ionizing radiation").

  1. QB Lu, Effects and Applications of Ultrashort-Lived Prehydrated Electrons in Radiation Biology and Radiotherapy of Cancer, Mutation Research: Reviews in Mutation Research 704, 190–199(2010). The term, "femtomedicine", was coined in this paper though it also appeared in my earlier conference abstract (http://ma.ecsdl.org/content/MA2010-01/19/1043.full.pdf ).

  1. CR Wang, J Nguyen and QB Lu, Bond Breaks of Nucleotides by Dissociative Electron Transfer of Nonequilibrium Prehydrated Electrons: A New Molecular Mechanism for Reductive DNA Damage, J. Am. Chem. Soc. 131, 11320-11322(2009).  Highlighted in a News & Views article by Prof. Leon Sanche in Nature 461, 358-359(2009).

The Ozone Hole and Global Climate Change:

  1. QB Lu, A monograph "New Theories and Predictions on the Ozone Hole and Climate Change", World Scientific Publishing Co. (New Jersey, London, Singapore, July 2015), 308 pages. (Invited book). In contrast to other climate models, Lu’s theoretical models are in excellent (the best) agreements with the observations on the ozone hole and global surface temperature changes.  See a Press Release by WSPC, http://www.worldscientific.com/page/pressroom/2015-07-15-01 .

  1. QB Lu, Cosmic-Ray-Driven Reaction and Greenhouse Effect of Halogenated Molecules: Culprits for Atmospheric Ozone Depletion and Global Climate Change, Int. J. Modern Phys B27 (2013) 1350073 (38 pages), available online at: www.worldscientific.com/doi/abs/10.1142/S0217979213500732 ; an earlier version was published at http://arxiv.org/abs/1210.6844 .  A news release about the findings can be found at http://uwaterloo.ca/news/news/global-warming-caused-cfcs-not-carbon-dioxide-study-says.  The paper was also reported by a number of media such as Phys.org (http://phys.org/news/2013-05-global-chlorofluorocarbons-carbon-dioxide.html), Sciencedaily (http://www.sciencedaily.com/releases/2013/05/130530132443.htm), Wall Street Journal (http://online.wsj.com/article/SB10001424127887323844804578528841152512364.html), CTV, etc.

  1. QB Lu, On Cosmic-Ray-Driven Electron Reaction Mechanism for Ozone Hole and Chlorofluorocarbon Mechanism for Global Climate Change” was published at http://arxiv.org/ftp/arxiv/papers/1210/1210.1498.pdf .  This paper gives a response to the Atmospheric Environment paper by Grooss and Muller (2011) and includes the ACE-FTS-carrying Canadian SCISAT-1 satellite’s latitude cover plot, which shows that the “ACE-FTS data” presented in their 2011 AE and 2009 PRL papers are impossible to obtain from the data source.

  1. QB Lu, What is the Major Culprit for Global Warming: CFCs or CO2? Journal of Cosmology 8, 1846-1862(2010). A pdf of the paper can be found at http://journalofcosmology.com/QingBinLu.pdf .

  1. QB Lu, Cosmic-Ray-Driven Electron-Induced Reactions of Halogenated Molecules Adsorbed on Ice Surfaces: Implications for Atmospheric Ozone Depletion and Global Climate Change, Physics Reports 487, 141-167(2010) (http://dx.doi.org/10.1016/j.physrep.2009.12.002), published online on December 3rd 2009. In this paper, a long-term global cooling was first originally predicted, though the prediction first appeared in my rejected manuscripts earlier.

  1. QB Lu, Correlation between Cosmic Rays and Ozone Depletion, was submitted on August 7th 2008 and published in Physical Review Letters 102, 118501(2009) on March 19, 2009.  In this paper, Lu predicted one of the largest Antarctic ozone holes, which was confirmed by the observed data (Oct-Dec, 2008).

  1. QB Lu, L Sanche, Effects of Cosmic Rays on Atmospheric Chlorofluorocarbon Dissociation and Ozone Depletion. Phys. Rev. Lett. 87, 078501(2001). In this issue (http://journals.aps.org/prl/issues/87/7) of PRL, this paper was highlighted as the Featured Article [See APS Focus story: Ozone Layer Burned by Cosmic Rays, Physical Review Focus 8, 8 (August 2nd, 2001)], whereas the paper on solar neutrinos by the SNO Collaboration (Phys. Rev. Lett. 87, 071301) was highlighted on the cover, which led to the award of the 2015 Nobel Prize in Physics to the SNO project leader Professor Art McDonald [See Focus story Nobel Prize—Neutrinos Oscillate, Physics 8, 97 (October 7, 2015)].

  2. QB Lu, L Sanche, Enhanced dissociative electron attachment to CF2Cl2 by transfer of electrons in precursors to the solvated state in water and ammonia ice. Phys. Rev. B 63, 153403 (2001).

  1. QB Lu, TE Madey, Negative-Ion Enhancements in Electron-Stimulated Desorption of CF2Cl2 Coadsorbed with Nonpolar and Polar Gases on Ru(0001), Phys. Rev. Lett. 82, 4122-4125(17 May 1999).

  1. QB Lu, TE Madey, Giant enhancement of electron-induced dissociation of chlorofluorocarbons coadsorbed with water or ammonia ices: Implications for atmospheric ozone depletion. Journal of Chemical Physics 111, 2861-2864(1999). A New mechanism for the formation of the ozone hole was first proposed in this paper.



“The younger participants in this Discussion should take note how vigorously science rejects novelty. This rejection mechanism is as necessary as the one that operates in living organisms; it prevents the birth of monsters. However, it has the additional effect of making us inherently conservative.” John C. Polanyi, Faraday Discuss., 1997, 108, page 467



Welcome to Prof. Qing-Bin Lu’s Laboratory