This course will examine, in detail, the X-ray structure determination. An introduction about the nature of X-ray radiation and its use for the X-ray diffraction will be discussed, including Laue group, Bragg’s law, Miller indices, plane, reciprocal lattice, Ewald sphere and the different X-ray diffraction techniques. We will also study the basics such the unit cell, crystal systems, Bravais lattices, symmetry elements, point groups and space groups (the consequences of applying translational symmetry to point groups). Stereographic projection of point groups and the nomenclature of space group Tables will be included. We will determine also the systematic absences of the space group and symmetry elements, using the structure factor and Fourier syntheses. The second part of the course will concentrate on how to solve the phase problem, using the Heavy Atom (Patterson) Method or Direct Method. And the last part we will focus on Crystal Data Collection, Data Reduction and Structure refinement, which is illustrated with examples from all synthetic disciplines (inorganic, organometallic and organic).
Lecture time : From 1 - 2:20pm on Tuesday and Thursday in EIT 2053
starting September -11 - 2012 for CHEM410/CHEM712
Office hours: Monday and Wednesday: From 1:30 - 2:30pm
1. Assignments: 20%
2. Presentation: 20%
4. midterm: 30%
5. Final exam 30%